NGFI-A-binding protein 1


In humans, the NGFI-A-binding protein 1, or nerve growth factor-induced protein A, comes from the protein-coding gene called NAB1 (chromosome 2q32.3-33) and is a potent regulator of glucocorticoid receptors in the hippocampus. It is also known as Zif268, EGR1, Krox-24 and ZENK.

The transcription factor NGFI-A regulates the expression of a gene called NR3C1; in particular its promoter in rats because the non-coding exon 1-region in the hippocampal glucocorticoid receptor has a promoter region, exon 1(7), with a binding site for NGFI-A.

References:

McGowan, P. et al. (2009). Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature neuroscience, 12(3), pp.342–348.

Weaver, G. et.al. (2004). Epigenetic programming by maternal behavior. Nature neuroscience, 7(8), pp.847–854